Phenylethyl Resorcinol (SymWhite) for Skin: Benefits and Products

  • It is a phenolic compound derived from pine bark
  • The skin advantages of phenylethyl resorcinol incorporate antioxidant and brightening consequences
  • It addresses uneven tone, darkish places, melasma and publish-zits marks
  • Phenylethyl resorcinol will work by inhibiting tyrosinase exercise
  • It is safe for pores and skin when employed in concentrations below 1%
  • It can be paired with most skincare actives like vitamin C

If you have fought dark spots and uneven tone, prospects are you arrived across an ingredient referred to as phenylethyl resorcinol, which also goes by Symwhite 377. According to investigate, this tricky to pronounce dude is thought to be one particular of the greatest melanin suppressors made use of in skincare formulations, having skin whitening outcomes 20 times extra powerful than kojic acid.[1]

Even far more, this resorcinol spinoff serves as the main selling pitch in lots of brightening goods coming from the most notable brands like SkinMedica, La Roche-Posay, and Sesderma. Almost nothing so praiseworthy can move us by with out remaining observed. That’s why we scoured the world wide web and did a lot of investigation to discover anything about phenylethyl resorcinol for pores and skin, its added benefits, how harmless it is, and the best items made up of it.

Intrigued? Maintain scrolling.

What is phenylethyl resorcinol?

Phenylethyl resorcinol, also recognized as Symwhite 377, is a white crystalline phenolic compound derived from pine bark produced to goal skin discoloration. As for skincare, phenylethyl resorcinol is a potent pores and skin whitening agent that acts as an antioxidant and tyrosinase inhibitor, typically employed to encourage a far more even-hunting complexion.[1]

FYI, this artificial compound is created from resorcinol (hence the title) which is an isomer just like hydroquinone sharing the identical molecular formula but a a little distinctive composition.[2] In truth, there are very a couple of resorcinol derivatives that specific brightening and depigmenting advantages, but phenylethyl resorcinol stands as the most researched and tolerable a single, together with butyl resorcinol.[3]

Phenylethyl resorcinol added benefits for pores and skin

While resorcinol on your own is more made use of to fight situations these kinds of as acne breakouts and dermatitis, phenylethyl resorcinol entered the skincare globe as a promising pores and skin lightening agent. When topically applied, its major function is to lower melanin information in cells by binding to tyrosinase and blocking the enzyme exercise responsible for pigment generation.[1][3][6] But the record of rewards goes on as phenylethyl resorcinol is also an antioxidant that helps scavenge totally free radicals and reduce pigmentation brought on by UV publicity.[1]

Given every little thing, phenylethyl resorcinol is an superb compound to brighten your skin and fade present discoloration — reports counsel that a focus of .5% is as strong as 1% kojic acid.[4] For the file, through a single review, a cream made up of phenylethyl resorcinol enhanced the physical appearance of uneven tone and decreased hyperpigmentation by up to 43% immediately after a 12-week procedure, earning it a great alternative to hydroquinone.[5]

On the other hand, regardless of all of the above, phenylethyl resorcinol is not the least difficult component to add to a skincare solution since it has lousy water solubility and is extremely susceptible to degradation when uncovered to light. The stressing section is that the poor h2o solubility may restrict its absorption into the pores and skin, creating it fewer effective. But the good thing is, most goods use encapsulation units to raise the supply and balance of phenylethyl resorcinol, protecting its benefits to the fullest.

Is it harmless?

While phenylethyl resorcinol is regarded as safe for pores and skin, it can cause irritation when employed in concentrations previously mentioned 1%. It’s also an component that really should be prevented through pregnancy and breastfeeding considering the fact that there’s not adequate investigate to verify how it reacts in these conditions.

How to use

Phenylethyl resorcinol in skincare is used in all kinds of products, including lotions, toners, serums, and sunscreens, as an antioxidant and skin brightener. It’s also light sufficient to be made use of daily as a part of your early morning and evening routines. Due to its lower solubility, resorcinol operates most effective when used to susceptible skin (like after a dermaroller or chemical peel), which permits additional resorcinol to penetrate the pores and skin.

Last but not the very least, phenylethyl resorcinol can be paired with other skin-lightening actives these as vitamin C, glutathione, kojic acid, retinol, and resveratrol for more intensive brightening outcomes.

Merchandise with phenylethyl resorcinol

Beneath are the greatest skincare products and solutions infused with phenylethyl resorcinol that function to market a far more radiant and brighter complexion whilst fading dark spots for a correctly even skin tone.


  1. Kim BS, Na YG, Choi JH, et al. The Enhancement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid CarriersNanomaterials (Basel). 20177(9):241. Published 2017 Aug 28. doi:10.3390/nano7090241
  2. Nationwide Center for Biotechnology Information and facts (2022). PubChem Compound Summary for CID 5054, Resorcinol. Retrieved April 26, 2022 from
  3. Tokudome, Y. Hoshi, T. Mori, S. Hijikuro, I. Synthesis of Resorcinol Derivatives and their Outcomes on Melanin Creation. Cosmetics 2020, 7, 55.
  4. Prasetyadi Mawardi, Mardiana (2020) The Big difference of Melanin Index in Therapy of Melasma Making use of Non-Hydroquinone Product and Kligman’s System. Clin Res Dermatol Open Entry 7(3): 1-4. DOI: 10.15226/2378-1726/7/3/001116
  5. Gold MH, Biron J. Efficacy of a novel hydroquinone-free of charge skin-brightening product in patients with melasma. J Cosmet Dermatol. 2011 Sep10(3):189-96. doi: 10.1111/j.1473-2165.2011.00573.x.
  6. Kang M, Park SH, Park SJ, Oh SW, Yoo JA, Kwon K, Kim J, Yu E, Cho JY, Lee J. p44/42 MAPK signaling is a prime concentrate on activated by phenylethyl resorcinol in its anti-melanogenic action. Phytomedicine. 2019 May possibly58:152877. doi: 10.1016/j.phymed.2019.152877. Epub 2019 Feb 26.